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. 2013 Mar 1;18(2):e241-5.
doi: 10.4317/medoral.18351.

Exploring the concept of "inflammatory angiogenesis" in keratocystic odontogenic tumor

Mojgan Alaeddini  1 , Esmat Mostafaloo, Omid Mirmohammadkhani, Nosratollah Eshghyar, Shahroo Etemad-Moghadam
Affiliations

Exploring the concept of "inflammatory angiogenesis" in keratocystic odontogenic tumor

Mojgan Alaeddini et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Objective: The aim of the present study was to investigate the role of inflammation in angiogenesis of keratocystic odontogenic tumor (KCOT).

Study design: Twenty inflamed and 20 non-inflamed KCOTs were selected based on quantitative scoring of inflammation which was also applied on 20 radicular cysts. Microvessel density was assessed in all samples using CD34 antibody and angiogenesis was compared between the three groups. Statistical analysis was performed using one-way analysis of variance followed by post-hoc Scheffe test and P values less than 0.05 were considered significant.

Results: A statistically significant difference in angiogenesis was found between radicular cysts and both inflamed and non-inflamed KCOTs (P < 0.001), but not between inflamed and non-inflamed KCOTs (P =0.347).

Conclusion: Based on the results obtained in the present study, it seems that the effect of inflammation on angiogenesis in KCOT is minimal. However further investigation using other methods of evaluation is suggested to fully clarify the role of "inflammatory angiogenesis" in this neoplasm.

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Figures

Figure 1
Figure 1
Microvessel density assessed by immunohistochemistry using monoclonal CD34 antibody in a representative noninflamed keratocystic odontogenic tumor (original magnification x400).
Figure 2
Figure 2
Microvessel density assessed by immunohistochemistry using monoclonal CD34 antibody in a representative inflamed keratocystic odontogenic tumor (original magnification x400).
Figure 3
Figure 3
Microvessel density assessed by immunohistochemistry using monoclonal CD34 antibody in a representative radicular cyst (original magnification x400).
See this image and copyright information in PMC

References

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