Diabetes mellitus and cancer in Werner syndrome
- PMID: 23386316
- PMCID: PMC3669637
- DOI: 10.1007/s00592-013-0456-z
Diabetes mellitus and cancer in Werner syndrome
Abstract
Onishi et al. recently reported here an association of diabetes mellitus (DM) with neoplasm type in newly identified patients with Werner syndrome (WS), an autosomal recessive cancer predisposition syndrome with features of premature aging that include a high risk of DM (Onishi et al. in Acta Diabetol 49(Suppl 1):259-260, 2012; Epstein et al. in Medicine 45:177-121, 1966). In contrast, we did not detect an association between DM and neoplasm type in an independent WS cohort we assembled to determine the histopathologic spectrum and type-specific risk of neoplasia in WS.
Conflict of interest statement
Conflict of interest: none.
Comment on
-
Japanese diabetic patients with Werner syndrome exhibit high incidence of cancer.Acta Diabetol. 2012 Dec;49 Suppl 1:S259-60. doi: 10.1007/s00592-012-0424-z. Epub 2012 Aug 8. Acta Diabetol. 2012. PMID: 22872450 No abstract available.
References
-
- Onishi S, Takemoto M, Ishikawa T, Okabe E, Ishibashi R, He P, Kobayashi K, Fujimoto M, Kawamura H, Yokote K. Japanese diabetic patients with Werner syndrome exhibit high incidence of cancer. Acta Diabetol. 2012;49(Suppl 1):259–260. - PubMed
-
- Epstein CJ, Martin GM, Schultz AL, Motulsky AG. Werner's syndrome: A review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine. 1966;45:177–221. - PubMed
-
- Montecucco C, Attardo-Parrinello G, Brambilla G, Chérié-Lignière EL, Ascari E. Improvement of hyperinsulinemic diabetes following removal of a meningioma in Werner's syndrome: a case report. Acta Diabetol Lat. 1984;21:193–197. - PubMed
-
- Kobayashi S, Gibo H, Sugita K, Komiya I, Yamada T. Werner's syndrome associated with meningioma. Neurosurgery. 1980;7:517–520. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical