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Comment
. 2013 Feb 5;6(261):pe5.
doi: 10.1126/scisignal.2003820.

Therapeutic hints from analyzing the attractor landscape of the p53 regulatory circuit

Wei Wang  1
Affiliations
Comment

Therapeutic hints from analyzing the attractor landscape of the p53 regulatory circuit

Wei Wang. Sci Signal. .

Abstract

Genes are interconnected in the cell to form a genetic network that regulates cell fate. Targeting multiple genes is expected to be more effective in developing therapeutics than targeting single genes. A recent study demonstrated the possibility of systematically searching for such combinatorial treatments by characterizing the attractor landscape of the p53 regulatory circuit.

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