Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2013 Feb;14(2):228-9.
doi: 10.1097/PCC.0b013e31826775cd.

Drug dosing during hypothermia: to adjust, or not to adjust, that is the question

Samuel M Poloyac, Philip E Empey
Editorial

Drug dosing during hypothermia: to adjust, or not to adjust, that is the question

Samuel M Poloyac et al. Pediatr Crit Care Med. 2013 Feb.
No abstract available

PubMed Disclaimer

Comment on

References

    1. Shankaran S, Pappas A, Laptook AR, et al. Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy. Pediatrics. 2008;122(4):e791–798. - PMC - PubMed
    1. Shankaran S, Pappas A, McDonald SA, et al. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med. 2012;366(22):2085–2092. - PMC - PubMed
    1. Empey PE, Miller TM, Philbrick AH, Melick J, Kochanek PM, Poloyac SM. Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest. Crit Care Med. 2011 - PMC - PubMed
    1. Fritz HG, Holzmayr M, Walter B, Moeritz KU, Lupp A, Bauer R. The effect of mild hypothermia on plasma fentanyl concentration and biotransformation in juvenile pigs. Anesth Analg. 2005;100(4):996–1002. - PubMed
    1. Koren G, Barker C, Goresky G, et al. The influence of hypothermia on the disposition of fentanyl--human and animal studies. Eur J Clin Pharmacol. 1987;32(4):373–376. - PubMed