Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Mar;13(3):161-71.
doi: 10.1038/nrc3460. Epub 2013 Feb 7.

Tracking cells in their native habitat: lineage tracing in epithelial neoplasia

Maria P Alcolea  1 , Philip H Jones
Affiliations
Review

Tracking cells in their native habitat: lineage tracing in epithelial neoplasia

Maria P Alcolea et al. Nat Rev Cancer. 2013 Mar.

Abstract

For tumours to develop, mutations must disrupt tissue homeostasis in favour of deregulated proliferation. Genetic lineage tracing has uncovered the behaviour of proliferating cells that underpins the maintenance of epithelial tissues and the barriers that are broken in neoplastic transformation. In this Review, we focus on new insights revealed by quantifying the behaviour of normal, preneoplastic and tumour cells in epithelia in transgenic mice and consider their potential importance in humans.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nat Biotechnol. 2004 Apr;22(4):411-7 - PubMed
    1. Cell Stem Cell. 2011 May 6;8(5):511-24 - PubMed
    1. Nucleic Acids Res. 1995 May 25;23(10):1686-90 - PubMed
    1. Cell. 2012 Jan 20;148(1-2):349-61 - PubMed
    1. J Invest Dermatol. 2012 Apr;132(4):1263-71 - PubMed

LinkOut - more resources