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Review
. 2013 Mar;13(3):161-71.
doi: 10.1038/nrc3460. Epub 2013 Feb 7.

Tracking cells in their native habitat: lineage tracing in epithelial neoplasia

Maria P Alcolea  1 , Philip H Jones
Affiliations
Review

Tracking cells in their native habitat: lineage tracing in epithelial neoplasia

Maria P Alcolea et al. Nat Rev Cancer. 2013 Mar.

Abstract

For tumours to develop, mutations must disrupt tissue homeostasis in favour of deregulated proliferation. Genetic lineage tracing has uncovered the behaviour of proliferating cells that underpins the maintenance of epithelial tissues and the barriers that are broken in neoplastic transformation. In this Review, we focus on new insights revealed by quantifying the behaviour of normal, preneoplastic and tumour cells in epithelia in transgenic mice and consider their potential importance in humans.

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References

    1. Nat Biotechnol. 2004 Apr;22(4):411-7 - PubMed
    1. Cell Stem Cell. 2011 May 6;8(5):511-24 - PubMed
    1. Nucleic Acids Res. 1995 May 25;23(10):1686-90 - PubMed
    1. Cell. 2012 Jan 20;148(1-2):349-61 - PubMed
    1. J Invest Dermatol. 2012 Apr;132(4):1263-71 - PubMed

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