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. 2013 Feb 6;11(2):455-65.
doi: 10.3390/md11020455.

New casbane diterpenoids from a South China Sea soft coral, Sinularia sp

Jian Yin  1 , Min Zhao, Minshan Ma, Yuping Xu, Zheng Xiang, Yuepiao Cai, Jianyong Dong, Xinxiang Lei, Kexin Huang, Pengcheng Yan
Affiliations

New casbane diterpenoids from a South China Sea soft coral, Sinularia sp

Jian Yin et al. Mar Drugs. .

Abstract

Six new casbane diterpenoids, named as sinularcasbanes A-F (1-6), along with six known analogues 7-12, were isolated from a South China Sea soft coral, Sinularia sp. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against selected cancer cell lines and the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages.

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Figures

Figure 1
Figure 1
Structures of compounds 1–12.
Figure 2
Figure 2
NOESY correlations of compounds 1, 3, 5, and 6.
Figure 3
Figure 3
COSY and HMBC correlations of compounds 1–3 and 5.
See this image and copyright information in PMC

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