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. 1977 Mar 1;145(3):500-7.
doi: 10.1084/jem.145.3.500.

Histocompatibility antigen-activated cytotoxic T lymphocytes. I. Estimates of the absolute frequency of killer cells generated in vitro

K F Lindahl  1 , D B Wilson
Affiliations

Histocompatibility antigen-activated cytotoxic T lymphocytes. I. Estimates of the absolute frequency of killer cells generated in vitro

K F Lindahl et al. J Exp Med. .

Abstract

A sensitive procedure employing limiting dilution of activated lymphocytes and 51Cr release from highly labeled target cells was used to derive minimal estimates of the absolute frequency of cytotoxic T lymphocytes (CTL) present in a population of mouse lymphocytes activated to alloantigens of the major histocompatibility complex in bulk mixed lymphocyte cultures. From this figure (0.7-1.2%), the maximal rate of target cell killing could be calculated to be approximately 4 targets/CTL/hour.

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References

    1. J Immunol. 1975 Jul;115(1):261-7 - PubMed
    1. J Exp Med. 1977 Mar 1;145(3):508-22 - PubMed
    1. Nature. 1976 Oct 28;263(5580):769-71 - PubMed
    1. Cell Immunol. 1973 Oct;9(1):127-41 - PubMed
    1. Adv Immunol. 1974;18:67-132 - PubMed

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