Notching up on the cellular origins of intrahepatic cholangiocarcinoma

Affiliations

Comment

Alphonse E Sirica. Hepatology. 2013 Apr.

. 2013 Apr;57(4):1668-71.

doi: 10.1002/hep.26313.

¹ Division of Cellular and Molecular Pathogenesis Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

No abstract available

Comment on

Cholangiocarcinomas can originate from hepatocytes in mice.
Fan B, Malato Y, Calvisi DF, Naqvi S, Razumilava N, Ribback S, Gores GJ, Dombrowski F, Evert M, Chen X, Willenbring H. Fan B, et al. J Clin Invest. 2012 Aug;122(8):2911-5. doi: 10.1172/JCI63212. Epub 2012 Jul 17. J Clin Invest. 2012. PMID: 22797301 Free PMC article.
Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes.
Sekiya S, Suzuki A. Sekiya S, et al. J Clin Invest. 2012 Nov;122(11):3914-8. doi: 10.1172/JCI63065. J Clin Invest. 2012. PMID: 23023701 Free PMC article.