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Clinical Trial
. 1990 Jan;40(1):29-34.
doi: 10.1016/0304-3959(90)91047-M.

The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy

Flemming W Bach  1 , Troels S Jensen, Jens Kastrup, Bent Stigsby, Anders Dejgård
Affiliations
Clinical Trial

The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy

Flemming W Bach et al. Pain. 1990 Jan.

Abstract

In a double-blind controlled design, 7 patients with painful diabetic neuropathy received lidocaine 5 mg/kg or saline intravenously over a period of 30 min. Thermal sensibility quantified by thermotest was not affected by lidocaine. In 3 of the patients nociceptive flexion reflex thresholds could be determined. The threshold was increased by lidocaine and returned to pre-infusion level within 10 days. Lidocaine also increased the threshold in 4 healthy subjects, but did not affect the Hoffmann reflex. These results suggest that lidocaine exerts its pain-relieving effect on the spinal level in diabetic neuropathy.

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