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. 2011 Oct 7;4(s1):74-81.
doi: 10.2174/1875041901104010074.

Oxidative Stress in Critically Ill Children with Sepsis

Derek S Wheeler  1
Affiliations

Oxidative Stress in Critically Ill Children with Sepsis

Derek S Wheeler. Open Inflamm J. .

Abstract

Sepsis is one of the leading causes of death in critically ill patients in the intensive care unit. Sepsis accounts for significant morbidity and mortality in critically ill children as well. The pathophysiology of sepsis is characterized by a complex systemic inflammatory response, endothelial dysfunction, and alterations in the coagulation system, which lead to perturbations in the delivery of oxygen and metabolic substrates to the tissues, end-organ dysfunction, and ultimately death. Oxidative stress plays a crucial role as both a promoter and mediator of the systemic inflammatory response, suggesting potential targets for the treatment of critically ill children with the sepsis syndrome. Herein, we will provide a brief review of the role of oxidative and nitrosative stress in the pathophysiology of sepsis.

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Figures

Figure 1
Figure 1
Purine catabolism by the xanthine oxidoreductase (XOR) enzyme system.
Figure 2
Figure 2
Regulation of Redox Status in the Cell by the Thioredoxin (TRX) System
Figure 3
Figure 3
The toxic effects of ROS/RNS
See this image and copyright information in PMC

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