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. 2013 Feb 15;15(4):960-3.
doi: 10.1021/ol400149j. Epub 2013 Feb 7.

Concise synthetic routes to human insulin

Fa Liu  1 , Ethan Y Luo, David B Flora, John P Mayer
Affiliations

Concise synthetic routes to human insulin

Fa Liu et al. Org Lett. .

Abstract

We report a set of concise and efficient routes for the chemical synthesis of human insulin using a two- or three-step combination procedure that employs Trt, Acm, and t-Bu cysteine protection schemes. Starting with resin-bound assembled A and B chains, human insulin can be obtained within the span of a single work day in 5.4% overall yield based on the crude A or B chain.

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