doi: 10.1084/jem.145.3.743.
Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells
Affiliations
- PMID: 233911
- PMCID: PMC2180716
- DOI: 10.1084/jem.145.3.743
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Prevention of IgG2a production as a result of allotype-specific interaction between T and B cells
J Exp Med.
.
Abstract
BALB/c T cells, which can prevent normal C57BL IgG2a allotype (G2) production of Ig-congenic partner mice (C.B mice), are shown capable of preventing the growth and G2 production of a C.B plasmacytoma (CBPC 101). Such cytotoxic or suppressor T cells are clearly allotype-specific (G2 Tcs cells). And since CBPC 101 B cells do not require specific helper T cells in order to grow, we infer that G2-bearing B cells (normal or neoplastic) must be the direct target of G2 Tcs cells. This mode of T cell prevention of allotype production contrasts that reported for suppressor T cells in (BALB/c x SJL)F1 mice.
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