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Review
. 2013 Mar;42(1):81-7.
doi: 10.1016/j.ecl.2012.12.001. Epub 2012 Dec 28.

Central leucine sensing in the control of energy homeostasis

Gary J Schwartz  1
Affiliations
Review

Central leucine sensing in the control of energy homeostasis

Gary J Schwartz. Endocrinol Metab Clin North Am. 2013 Mar.

Abstract

This article reviews recent studies identifying two key brain regions as two critical nodes in the neural network where central leucine sensing contributes to whole body energy homeostasis: the mediobasal hypothalamus and the dorsal vagal complex of the caudal brainstem. Activation of these leucine sensing sites engages multiple determinants of energy balance, including glucose homeostasis, food intake, and adiposity.

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References

    1. Blouet C, Jo YH, Li X, Schwartz GJ. Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. J Neurosci. 2009;29:8302–8311. - PMC - PubMed
    1. Smith QR. The blood-brain barrier and the regulation of amino acid uptake and availability to brain. Adv Exp Med Biol. 1991;291:55–71. - PubMed
    1. Shigemitsu K, Tsujishita Y, Miyake H, Hidayat S, Tanaka N, et al. Structural requirement of leucine for activation of p70 S6 kinase. FEBS Lett. 1999;447:303–306. - PubMed
    1. Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature. 2004;431:200–205. - PubMed
    1. Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 2009;9:311–326. - PMC - PubMed

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