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Comment
. 2013 Feb 5;17(2):153-5.
doi: 10.1016/j.cmet.2013.01.010.

Lipid metabolism greases the stem cell engine

Clifford D L Folmes  1 , Sungjo Park, Andre Terzic
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Lipid metabolism greases the stem cell engine

Clifford D L Folmes et al. Cell Metab. .
Free article

Abstract

Metabolic plasticity is increasingly postulated to be vital in the transition between stemness maintenance and lineage specification. Knobloch et al. (2012) now demonstrate that regulation of lipogenesis by fatty acid synthase and Spot14-dependent malonyl-CoA supply determines the proliferative activity of resident neural stem cells, contributing to adult neurogenesis.

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