Comment
doi: 10.1016/j.stem.2013.01.012.
H2A.Z sets the stage in ESCs
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- PMID: 23395439
- DOI: 10.1016/j.stem.2013.01.012
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Comment
H2A.Z sets the stage in ESCs
Cell Stem Cell.
.
Free article
Abstract
ESCs undergo drastic changes in chromatin states during differentiation. Two recent papers in Cell (Li et al., 2012) and Cell Stem Cell (Hu et al., 2013) demonstrate that histone variant H2A.Z plays essential roles in this process by preconfiguring nucleosomes for depletion and recruiting transcription cofactors to cis-regulatory elements.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation.Cell. 2012 Dec 21;151(7):1608-16. doi: 10.1016/j.cell.2012.11.018. Cell. 2012. PMID: 23260146 Free PMC article.
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H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation.Cell Stem Cell. 2013 Feb 7;12(2):180-92. doi: 10.1016/j.stem.2012.11.003. Epub 2012 Dec 20. Cell Stem Cell. 2013. PMID: 23260488 Free PMC article.
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