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Review
. 2013 Sep:62:65-75.
doi: 10.1016/j.freeradbiomed.2013.01.032. Epub 2013 Feb 8.

Manganese neurotoxicity and the role of reactive oxygen species

Ebany J Martinez-Finley  1 , Claire E Gavin  2 , Michael Aschner  3 , Thomas E Gunter  4
Affiliations
Review

Manganese neurotoxicity and the role of reactive oxygen species

Ebany J Martinez-Finley et al. Free Radic Biol Med. 2013 Sep.

Abstract

Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

Keywords: DA autoxidation; Free radicals; Manganese; Manganism; Mitochondrial dysfunction; Reactive oxygen species.

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Figures

Figure 1
Figure 1
Mn Transport
See this image and copyright information in PMC

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