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. 2013 Feb 7;3(2):e002270.
doi: 10.1136/bmjopen-2012-002270. Print 2013.

Dietary patterns and colorectal cancer recurrence and survival: a cohort study

Yun Zhu  1 , Hao Wu, Peizhong Peter Wang, Sevtap Savas, Jennifer Woodrow, Tyler Wish, Rong Jin, Roger Green, Michael Woods, Barbara Roebothan, Sharon Buehler, Elizabeth Dicks, John R McLaughlin, Peter T Campbell, Patrick S Parfrey
Affiliations

Dietary patterns and colorectal cancer recurrence and survival: a cohort study

Yun Zhu et al. BMJ Open. .

Abstract

Objective: To examine the association between dietary patterns and colorectal cancer (CRC) survival.

Design: Cohort study.

Setting: A familial CRC registry in Newfoundland.

Participants: 529 newly diagnosed CRC patients from Newfoundland. They were recruited from 1999 to 2003 and followed up until April 2010.

Outcome measure: Participants reported their dietary intake using a food frequency questionnaire. Dietary patterns were identified with factor analysis. Multivariable Cox proportional hazards models were employed to estimate HR and 95% CI for association of dietary patterns with CRC recurrence and death from all causes, after controlling for covariates.

Results: Disease-free survival (DFS) among CRC patients was significantly worsened among patients with a high processed meat dietary pattern (the highest vs the lowest quartile HR 1.82, 95% CI 1.07 to 3.09). No associations were observed with the prudent vegetable or the high-sugar patterns and DFS. The association between the processed meat pattern and DFS was restricted to patients diagnosed with colon cancer (the highest vs the lowest quartile: HR 2.29, 95% CI 1.19 to 4.40) whereas the relationship between overall survival (OS) and this pattern was observed among patients with colon cancer only (the highest vs the lowest quartile: HR 2.13, 95% CI 1.03 to 4.43). Potential effect modification was noted for sex (p value for interaction 0.04, HR 3.85 for women and 1.22 for men).

Conclusions: The processed meat dietary pattern prior to diagnosis is associated with higher risk of tumour recurrence, metastasis and death among patients with CRC.

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References

    1. Canadian Cancer Statistics 2012 Toronto, ON: Canadian Cancer Society's Steering Committee on Cancer Statistics. Canadian Cancer Society, 2012
    1. Norat T, Chan D, Lau R, et al. WCRF/AICR Systematic Literature Review Continuous Update Project Report. Imperial College London, 2010
    1. Dixon LB, Balder HF, Virtanen MJ, et al. Dietary patterns associated with colon and rectal cancer: results from the Dietary Patterns and Cancer (DIETSCAN) Project. Am J Clin Nutr 2004;80:1003–11 - PubMed
    1. Terry P, Hu FB, Hansen H, et al. Prospective study of major dietary patterns and colorectal cancer risk in women. Am J Epidemiol 2001;154:1143–9 - PubMed
    1. Kwan ML, Weltzien E, Kushi LH, et al. Dietary patterns and breast cancer recurrence and survival among women with early-stage breast cancer. J Clin Oncol 2009;27:919–26 - PMC - PubMed