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. 1990 Jun;46(6):1017-23.

Assignment of the locus for Waardenburg syndrome type I to human chromosome 2q37 and possible homology to the Splotch mouse

C Foy  1 , V Newton, D Wellesley, R Harris, A P Read
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Assignment of the locus for Waardenburg syndrome type I to human chromosome 2q37 and possible homology to the Splotch mouse

C Foy et al. Am J Hum Genet. 1990 Jun.

Abstract

We have demonstrated close linkage between the locus for the autosomal dominant Waardenburg syndrome type I and the placental alkaline phosphatase locus on chromosome 2q37. In five families the peak lod score was 4.76 at a recombination fraction of .023. In the mouse the Splotch locus maps to near the homologous position. Splotch mice have white spotting and hearing defects, suggesting that Splotch may be the murine homologue of Waardenburg syndrome type I.

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References

    1. JAMA. 1966 Feb 14;195(7):519-23 - PubMed
    1. Nature. 1966 Jan 8;209(5019):219-20 - PubMed
    1. Arch Dermatol. 1967 Feb;95(2):176-86 - PubMed
    1. Proc R Soc Med. 1972 Jul;65(7):601-2 - PubMed
    1. Br J Dermatol. 1974 Mar;90(3):255-62 - PubMed

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