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Randomized Controlled Trial
. 2013 Jan;22(1):54-9.
doi: 10.1111/j.1521-0391.2013.12029.x.

Major depression and PTSD in pregnant smokers enrolled in nicotine gum treatment trial

Ellen Dornelas  1 , Cheryl Oncken, John Greene, Heather Z Sankey, Henry R Kranzler
Affiliations
Randomized Controlled Trial

Major depression and PTSD in pregnant smokers enrolled in nicotine gum treatment trial

Ellen Dornelas et al. Am J Addict. 2013 Jan.

Abstract

Background and objectives: Pregnant women face considerable barriers to smoking cessation. The purpose of this study was to determine the prevalence of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) and response to smoking cessation treatment in pregnant smokers participating in a randomized, placebo-controlled trial of nicotine gum.

Methods: Participants were 194 low-income, ethnically diverse pregnant smokers.

Results: Utilizing a structured interview, 45% and 18% of the subjects met criteria for a lifetime diagnosis of MDD and PTSD, respectively. There was no difference in response to treatment, based on the presence of either of these psychiatric disorders.

Conclusions: Cumulatively, these findings provide evidence of the high degree of unmet mental health needs in pregnant smokers.

Scientific significance: Pregnant women with a history of MDD and PTSD appear to be as likely to benefit from smoking cessation treatment as those without such a history.

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