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. 2013 Feb 27;135(8):2955-8.
doi: 10.1021/ja312711c. Epub 2013 Feb 18.

Silver-mediated trifluoromethylation-iodination of arynes

Yuwen Zeng  1 , Laijun Zhang, Yanchuan Zhao, Chuanfa Ni, Jingwei Zhao, Jinbo Hu
Affiliations

Silver-mediated trifluoromethylation-iodination of arynes

Yuwen Zeng et al. J Am Chem Soc. .

Abstract

An unprecedented silver-mediated vicinal trifluoromethylation-iodination of arynes that quickly introduces CF(3) and I groups onto aromatic rings in a single step to give o-trifluoromethyl iodoarenes has been developed. A new reactivity of AgCF(3) has been revealed, and 2,2,6,6-tetramethylpiperidine plays an important role in this difunctionalization reaction.

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