Neurodegenerative disease: altered DNA methylation and RNA splicing could be key mechanisms in Huntington disease
- PMID: 23399643
- DOI: 10.1038/nrneurol.2013.23
Neurodegenerative disease: altered DNA methylation and RNA splicing could be key mechanisms in Huntington disease
Comment on
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Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2366-70. doi: 10.1073/pnas.1221891110. Epub 2013 Jan 22. Proc Natl Acad Sci U S A. 2013. PMID: 23341618 Free PMC article.
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Extensive changes in DNA methylation are associated with expression of mutant huntingtin.Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2354-9. doi: 10.1073/pnas.1221292110. Epub 2013 Jan 22. Proc Natl Acad Sci U S A. 2013. PMID: 23341638 Free PMC article.
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