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Case Reports
. 2013 May;19(5):E233-5.
doi: 10.1111/1469-0691.12142. Epub 2013 Feb 12.

Intrapatient emergence of OXA-247: a novel carbapenemase found in a patient previously infected with OXA-163-producing Klebsiella pneumoniae

S Gomez  1 , F Pasteran, D Faccone, M Bettiol, O Veliz, D De Belder, M Rapoport, B Gatti, A Petroni, A Corso
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Free article
Case Reports

Intrapatient emergence of OXA-247: a novel carbapenemase found in a patient previously infected with OXA-163-producing Klebsiella pneumoniae

S Gomez et al. Clin Microbiol Infect. 2013 May.
Free article

Abstract

Two genetically related Klebsiella pneumoniae strains carrying OXA-type carbapenemases were isolated from a single patient 1 month apart. Kpn163 harboured OXA-163 and Kpn247 a new variant named OXA-247 that showed susceptibility to carbapenems and expanded-spectrum cephalosporins similar to OXA-48. Our epidemiological, biochemical and molecular results suggest the intrapatient emergence of blaOXA -247 from blaOXA -163.

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