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Case Reports
. 1990 Jun 15;65(12):2686-8.
doi: 10.1002/1097-0142(19900615)65:12<2686::aid-cncr2820651215>3.0.co;2-d.

Hypothyroidism and goiter in a patient during treatment with interleukin-2

V J Mattijssen  1 , P H De Mulder, P A Van Liessum, F H Corstens, C R Franks, D J Wagener
Affiliations
Case Reports

Hypothyroidism and goiter in a patient during treatment with interleukin-2

V J Mattijssen et al. Cancer. .

Abstract

The development of transient hypothyroidism and goiter in a patient with a metastasized malignant melanoma during treatment with recombinant interleukin-2 (rIL-2) and dacarbazine is reported. Signs of autoimmune thyroiditis became apparent 2 weeks after the start of treatment and disappeared after treatment stopped. It is likely that rIL-2 was responsible by interfering with preexisting autoimmune thyroid disease. The possible mechanisms are discussed here. Patients with positive antithyroid microsomal antibody titers are prime candidates for rIL-2-induced thyroiditis.

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