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. 2013 Aug;23(8):1022-8.
doi: 10.1089/thy.2012.0562.

Thyroglobulin autoantibodies: is there any added value in the detection of thyroid autoimmunity in women consulting for fertility treatment?

David Unuane  1 , Brigitte Velkeniers, Ellen Anckaert, Johan Schiettecatte, Herman Tournaye, Patrick Haentjens, Kris Poppe
Affiliations

Thyroglobulin autoantibodies: is there any added value in the detection of thyroid autoimmunity in women consulting for fertility treatment?

David Unuane et al. Thyroid. 2013 Aug.

Abstract

Background: Thyroid autoimmunity (TAI) is frequent in infertile women, but to what extent thyroglobulin autoantibodies (Tg-Abs) contribute to TAI is unclear in the literature. The aims of the present study were to determine the prevalence of TAI in women consulting for fertility problems and to investigate the impact of isolated Tg-Abs, isolated thyroid peroxidase autoantibodies (TPO-Abs), and the presence of both autoantibody types on thyroid function. Furthermore, thyroid function was compared between women with and without TAI and between infertile and fertile women.

Methods: A cross-sectional data analysis nested within an ongoing prospective cohort study was performed in order to determine the prevalence of TAI in unselected women consulting our tertiary referral center for reproductive medicine (CRM). The women underwent a determination of serum thyrotropin (TSH), free thyroxine (FT4), TPO-Abs, and Tg-Abs. The cause of infertility, age, body-mass index (BMI), and smoking habits were recorded.

Results: The prevalence of TAI was 16% (163/992). In 8% of cases, both types of autoantibodies were present, in 5% isolated positive Tg-Abs were found, and 4% had isolated positive TPO-Abs (p=0.025 and p=0.003 respectively). The prevalence of TAI was significantly higher in infertile women as compared to that in fertile controls (19% vs. 13%; p=0.047). The median serum TSH level was significantly higher in the women with TAI and with isolated positive Tg-Abs compared to that in women without TAI (1.83 [1.44] and 1.90 [0.85] vs. 1.47 [0.94] mIU/L; p<0.001 respectively). The median FT4, age, BMI, and smoking habits were comparable between the study groups.

Conclusions: The prevalence of TAI was higher in infertile women as compared to fertile women consulting our CRM. Five percent of the women had isolated positive Tg-Abs and a significantly higher serum TSH compared to that in women without TAI.

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Figures

FIG. 1.
FIG. 1.
Prevalence of thyroid autoimmunity (TAI) in all patients screened, and flowchart of further analyses of thyroid function and infertility work-up. TPO-Abs, thyroid peroxidase autoantibodies; Tg-Abs, thyroglobulin autoantibodies.
See this image and copyright information in PMC

References

    1. Vanderpump MP. Tunbridge WM. French JM. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf) 1995;43:55–68. - PubMed
    1. Poppe K. Velkeniers B. Glinoer D. The role of thyroid autoimmunity in fertility and pregnancy. Nat Clin Pract Endocrinol Metab. 2008;4:394–405. - PubMed
    1. Krassas GE. Poppe K. Glinoer D. Thyroid function and human reproductive health. Endocr Rev. 2010;31:702–755. - PubMed
    1. Van den Boogaard E. Vissenberg R. Land J. Van Wely M. Van der Post J. Goddijn M. Bisschop P. Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review. Hum Reprod Update. 2011;17:605–619. - PubMed
    1. Thangaratinam S. Tan A. Knox E. Kilby M. Franklyn J. Coomarasamy A. Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence. BMJ. 2011;342:d2616. - PMC - PubMed

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