doi: 10.1021/ja400648w.
Epub 2013 Feb 25.
Palladium(0)-catalyzed alkynylation of C(sp3)-H bonds
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- PMID: 23406445
- DOI: 10.1021/ja400648w
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Palladium(0)-catalyzed alkynylation of C(sp3)-H bonds
J Am Chem Soc.
.
Abstract
The alkynylation of β-C(sp(3))-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyclic carbene (NHC) and Pd(0)/phosphine (PR3) catalysts. This is the first example of utilizing [AlkynylPd(II)L(n)] complexes to activate C(sp(3))-H bonds.
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