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. 2013 Mar 6;135(9):3387-90.
doi: 10.1021/ja400648w. Epub 2013 Feb 25.

Palladium(0)-catalyzed alkynylation of C(sp3)-H bonds

Jian He  1 , Masayuki Wasa, Kelvin S L Chan, Jin-Quan Yu
Affiliations

Palladium(0)-catalyzed alkynylation of C(sp3)-H bonds

Jian He et al. J Am Chem Soc. .

Abstract

The alkynylation of β-C(sp(3))-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyclic carbene (NHC) and Pd(0)/phosphine (PR3) catalysts. This is the first example of utilizing [AlkynylPd(II)L(n)] complexes to activate C(sp(3))-H bonds.

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