Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr;23(4):236-41.
doi: 10.1097/FPC.0b013e32835ea0b2.

Valproic acid pathway: pharmacokinetics and pharmacodynamics

Affiliations

Valproic acid pathway: pharmacokinetics and pharmacodynamics

Yogita Ghodke-Puranik et al. Pharmacogenet Genomics. 2013 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest

There are no conflicts of interest.

Figures

Fig. 1
Fig. 1
Graphic representation of the candidate genes involved in valproic acid (VPA) pharmacokinetics. A fully interactive version of this pathway is available online at PharmGKB at http://www.pharmgkb.org/pathway/PA165964265. CYP, cytochrome P450.
Fig. 2
Fig. 2
Graphic representation of the candidate genes involved in valproic acid (VPA) pharmacodynamics. A fully interactive version of this pathway is available online at PharmGKB at http://www.pharmgkb.org/pathway/PA165959313.

References

    1. Chateauvieux S, Morceau F, Dicato M, Diederich M. Molecular and therapeutic potential and toxicity of valproic acid. J Biomed Biotechnol. 2010 doi: 10.1155/2010/479364. Epub ahead of print. - DOI - PMC - PubMed
    1. Terbach N, Williams RS. Structure–function studies for the panacea, valproic acid. Biochem Soc Trans. 2009;37(Pt 5):1126–1132. - PubMed
    1. Serrano BB, Garcia Sanchez MJ, Otero MJ, Buelga DS, Serrano J, Dominguez-Gil A. Valproate population pharmacokinetics in children. J Clin Pharm Ther. 1999;24:73–80. - PubMed
    1. Blanco-Serrano B, Otero MJ, Santos-Buelga D, Garcia-Sanchez MJ, Serrano J, Dominguez-Gil A. Population estimation of valproic acid clearance in adult patients using routine clinical pharmacokinetic data. Biopharm Drug Dispos. 1999;20:233–240. - PubMed
    1. Aires CC, van Cruchten A, Ijlst L, de Almeida IT, Duran M, Wanders RJ, et al. New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA. J Hepatol. 2011;55:426–434. - PubMed

Publication types

MeSH terms

Substances