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Comment
. 2013 Mar 5;110(10):E858-9.
doi: 10.1073/pnas.1219306110. Epub 2013 Feb 13.

Proteome size as the major factor determining mutation rates

Steven E Massey
Comment

Proteome size as the major factor determining mutation rates

Steven E Massey. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Effective population size versus mutations/proteome size/cell divison, which includes a correction for the number of germ-line divisions in eukaryotes (obtained from ref. 4).
Fig. 2.
Fig. 2.
Proteome size versus mutation rate, including a correction for germ-line divisions in eukaryotes. Eukaryotes are in red.
See this image and copyright information in PMC

Comment in

Comment on

  • Drift-barrier hypothesis and mutation-rate evolution.
    Sung W, Ackerman MS, Miller SF, Doak TG, Lynch M. Sung W, et al. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18488-92. doi: 10.1073/pnas.1216223109. Epub 2012 Oct 17. Proc Natl Acad Sci U S A. 2012. PMID: 23077252 Free PMC article.

References

    1. Sung W, Ackerman MS, Miller SF, Doak TG, Lynch M. Drift-barrier hypothesis and mutation-rate evolution. Proc Natl Acad Sci USA. 2012;109(45):18488–18492. - PMC - PubMed
    1. Drake JW, Charlesworth B, Charlesworth D, Crow JF. Rates of spontaneous mutation. Genetics. 1998;148(4):1667–1686. - PMC - PubMed
    1. Massey SE. The proteomic constraint and its role in molecular evolution. Mol Biol Evol. 2008;25(12):2557–2565. - PubMed
    1. Lynch M. Evolution of the mutation rate. Trends Genet. 2010;26(8):345–352. - PMC - PubMed
    1. Garcia-Gonzalez A, Rivera-Rivera RJ, Massey SE. The presence of the DNA repair genes mutM, mutY, mutL and mutS is related to proteome size in bacterial genomes. Front Genet. 2012;3:3. - PMC - PubMed

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