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Meta-Analysis
. 2013 Jun;172(6):803-9.
doi: 10.1007/s00431-013-1966-y. Epub 2013 Feb 14.

Infantile hemangiomas and retinopathy of prematurity: clues to the regulation of vasculogenesis

Rachael M Hyland  1 , Katalin Komlósi, Brandon W Alleman, Marina Tolnai, Laura M Wood, Edward F Bell, Tibor Ertl
Affiliations
Meta-Analysis

Infantile hemangiomas and retinopathy of prematurity: clues to the regulation of vasculogenesis

Rachael M Hyland et al. Eur J Pediatr. 2013 Jun.

Abstract

Retinopathy of prematurity (ROP) and infantile hemangiomas are vascular disorders that may share common mechanisms. This study examined a potential clinical association between these disorders in populations of preterm infants at two hospitals in the USA and Hungary. Clinically collected data from infants with gestational ages less than 32 weeks born between May 1, 2007 and December 31, 2010 seen in the University of Iowa Children's Hospital or the Department of Obstetrics and Gynecology, University of Pécs, were abstracted from electronic medical records and entered into a study database. Demographic and clinical variables were examined as potential covariates to the disorders of interest. Data were initially analyzed by center and then combined through meta-analysis. Six hundred eighty-four subjects were studied: 236 from Pécs and 448 from Iowa. There were no significant demographic differences between populations. Univariate analysis on each study population yielded covariates to ROP in each population, including infantile hemangioma, which were entered into a logistic regression model. These models were combined through random-effects meta-analysis and demonstrated a significant relationship between infantile hemangioma and ROP (odds ratio = 1.84, 95 % confidence interval 1.08-3.12).

Conclusion: Infantile hemangioma and ROP co-occur in premature infant populations. Further studies are needed to investigate the pathogenesis of both disorders.

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Conflict of interest statement

The authors declare that they have no financial relationships and no conflict of interest relevant to this article to disclose.

Figures

Fig. 1
Fig. 1
Forest plot for meta-analysis of data from current study by study site
Fig. 2
Fig. 2
Forest plot for meta-analysis of data from current study and study of Praveen et al [35]
See this image and copyright information in PMC

References

    1. Amir J, Metzker A, Krikler R, Reisner SH. Strawberry hemangioma in preterm infants. Pediatr Dermatol. 1986;3(4):331–332. - PubMed
    1. Ashton N, Ward B, Serpell G. Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia. Br J Ophthalmol. 1954;38(7):397–432. - PMC - PubMed
    1. Boscolo E, Mulliken JB, Bischoff J. VEGFR-1 mediates endothelial differentiation and formation of blood vessels in a murine model of infantile hemangioma. Am J Pathol. 2011;179(5):2266–2277. - PMC - PubMed
    1. Boye E, Jinnin M, Olsen BR. Infantile hemangioma: challenges, new insights, and therapeutic promise. J Craniofac Surg. 2009;20(Suppl 1):678–684. - PubMed
    1. Chen J, Joyal JS, Hatton CJ, Juan AM, Pei DT, Hurst CG, Xu D, Stable A, Hellstrom A, Smith LEH. Propranolol inhibition of β-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012;53(6):2968–2977. - PMC - PubMed

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