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. 2013 Mar;5(3):937-941.
doi: 10.3892/etm.2013.893. Epub 2013 Jan 14.

Association of serum angiopoietin-1, angiopoietin-2 and angiopoietin-2 to angiopoietin-1 ratio with heart failure in patients with acute myocardial infarction

Shaomin Chen  1 , Lijun Guo, Baoxia Chen, Lijie Sun, Ming Cui
Affiliations

Association of serum angiopoietin-1, angiopoietin-2 and angiopoietin-2 to angiopoietin-1 ratio with heart failure in patients with acute myocardial infarction

Shaomin Chen et al. Exp Ther Med. 2013 Mar.

Abstract

The aim of the present study was to investigate the association of the serum angiopoietin (Ang)-1 and Ang-2 levels and the Ang-2 to Ang-1 ratio (Ang-2/Ang-1) with heart failure (HF) in patients with acute myocardial infarction (AMI) during hospitalization. The serum Ang-1 and Ang-2 levels of the AMI patients were measured at admission to hospital. The correlations between serum Ang-1, Ang-2 and Ang-2/Ang-1 with HF were examined. Among 103 patients, 20 developed HF during hospitalization. The serum Ang-2 level and Ang-2/Ang-1 were found to be significantly higher in the patients with HF than in the patients without HF (2,203.1±122.0 vs. 2,102.3±114.4 pg/ml, P=0.001 and 11.4±1.6×10(-2) vs. 10.6±1.1×10(-2), P=0.007, respectively). Serum Ang-2 level and Ang-2/Ang-1 were negatively correlated with left ventricular ejection fraction (LVEF; r=-0.352, P<0.001 and r=-0.365, P<0.001, respectively) and positively correlated with the natural logarithm of the level of N-terminal pro-B-type natriuretic peptide (LnNT-proBNP, r=0.367, P<0.001 and r=0.304, P=0.003, respectively) and peak cardiac troponin T (cTnT, r=0.421, P<0.001 and r=0.278, P=0.009, respectively). However, the serum Ang-1 level was not found to correlate significantly with LVEF (r= 0.194, P= 0.05), LnNT-proBNP (r=-0.116, P=0.266) or peak cTnT (r=-0.056, P=0.607). In multivariable logistic regression analysis, Ang-2 (P=0.031), Ang-2/Ang-1 (P=0.018) and NT-proBNP (P=0.001) were revealed to be independently associated with HF. The present study reveals that Ang-2 levels and Ang-2/Ang-1 are independent predictors of HF in AMI patients during hospitalization.

Keywords: acute myocardial infarction; angiopoietin; heart failure.

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Figures

Figure 1.
Figure 1.
(A) Serum Ang-2 levels and (B) Ang-2/Ang-1 were negatively correlated with LVEF. Ang, angiopoietin; Ang-2/Ang-1, Ang-2 to Ang-1 ratio; LVEF, left ventricular ejection fraction.
Figure 2.
Figure 2.
(A) Serum Ang-2 levels and (B) Ang-2/Ang-1 were positively correlated with LnNT-proBNP. Ang, angiopoietin; LnNT-proBNP, logarithmic N-terminal pro-B-type natriuretic peptide.
Figure 3.
Figure 3.
(A) Serum Ang-2 levels and (B) Ang-2/Ang-1 were positively correlated with peak cTnT. Ang, angiopoietin; cTnT, cardiac troponin T.
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