Etiology and prognosis of fulminant hepatitis and late-onset hepatic failure in Japan: Summary of the annual nationwide survey between 2004 and 2009
- PMID: 23409848
- DOI: 10.1111/j.1872-034X.2012.01105.x
Etiology and prognosis of fulminant hepatitis and late-onset hepatic failure in Japan: Summary of the annual nationwide survey between 2004 and 2009
Abstract
Aim: To summarize the annual nationwide survey on fulminant hepatitis (FH) and late-onset hepatic failure (LOHF) between 2004 and 2009 in Japan.
Methods: The annual survey was performed in a two-step questionnaire process to detail the clinical profile and prognosis of patients in special hospitals.
Results: Four hundred and sixty (n = 227 acute type; n = 233 subacute type) patients had FH and 28 patients had LOHF. The mean age of patients with FH and LOHF were 51.1 ± 17.0 and 58.0 ± 14.4 years, respectively. The causes of FH were hepatitis A virus in 3.0%, hepatitis B virus (HBV) in 40.2%, other viruses in 2.0%, autoimmune hepatitis in 8.3%, drug allergy-induced in 14.6% and indeterminate etiology in 29.6% of patients. HBV reactivation due to immunosuppressive therapy was observed in 6.8% of FH patients. The short-term survival rates of patients without liver transplantation (LT) were 48.7% and 24.2% for the acute and subacute type, respectively, and 13.0% for LOHF. The prognosis was poor in patients with HBV reactivation. The implementation rate for LT in FH patients was equivalent to that in the previous survey. The short-term survival rates of total patients, including LT patients, were 54.2% and 40.8% for the acute and subacute type, respectively, and 28.6% for LOHF.
Conclusion: The demographic features and etiology of FH patients has gradually changed. HBV reactivation due to immunosuppressive therapy is problematic. Despite advances in therapeutic approaches, the prognosis of patients without LT has not improved.
© 2013 The Japan Society of Hepatology.
Similar articles
-
Fulminant hepatitis and late onset hepatic failure in Japan.Hepatol Res. 2008 Jul;38(7):646-57. doi: 10.1111/j.1872-034X.2008.00322.x. Epub 2008 Mar 5. Hepatol Res. 2008. PMID: 18328067
-
Thirty-two years' experience of treating fulminant hepatitis in a Japanese single center.Hepatol Res. 2023 Apr;53(4):357-369. doi: 10.1111/hepr.13873. Epub 2023 Jan 10. Hepatol Res. 2023. PMID: 36541110
-
Nationwide survey of patients with acute liver failure and late-onset hepatic failure in Japan seen between 2016 and 2021.Hepatol Res. 2025 Jun;55(6):932-947. doi: 10.1111/hepr.14191. Epub 2025 Apr 15. Hepatol Res. 2025. PMID: 40317595
-
Changing etiologies and outcomes of acute liver failure: A perspective from Japan.J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:65-71. doi: 10.1111/j.1440-1746.2010.06574.x. J Gastroenterol Hepatol. 2011. PMID: 21199516 Review.
-
Management of Fulminant Hepatitis B.Curr Infect Dis Rep. 2019 Jun 4;21(7):25. doi: 10.1007/s11908-019-0682-9. Curr Infect Dis Rep. 2019. PMID: 31165271 Free PMC article. Review.
Cited by
-
Serum APOA4 Pharmacodynamically Represents Administered Recombinant Human Hepatocyte Growth Factor (E3112).Int J Mol Sci. 2021 Apr 27;22(9):4578. doi: 10.3390/ijms22094578. Int J Mol Sci. 2021. PMID: 33925510 Free PMC article.
-
A mouse model of subacute liver failure with ascites induced by step-wise increased doses of (-)-epigallocatechin-3-gallate.Sci Rep. 2019 Dec 2;9(1):18102. doi: 10.1038/s41598-019-54691-0. Sci Rep. 2019. PMID: 31792332 Free PMC article.
-
Acute Liver Failure Caused by the Transmission of Hepatitis B Virus from the Spouse after 38 Years of Marriage.Intern Med. 2019 Oct 15;58(20):2963-2968. doi: 10.2169/internalmedicine.3028-19. Epub 2019 Jun 27. Intern Med. 2019. PMID: 31243227 Free PMC article.
-
Hepatitis B reactivation characterized by HBsAg negativity and anti-HbsAg antibodies persistence in haematopoietic stem cell transplanted patient after lamivudine withdrawal.BMC Infect Dis. 2017 Aug 15;17(1):566. doi: 10.1186/s12879-017-2672-6. BMC Infect Dis. 2017. PMID: 28806922 Free PMC article.
-
The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury.J Gastroenterol. 2018 Jul;53(7):861-872. doi: 10.1007/s00535-017-1421-3. Epub 2017 Dec 19. J Gastroenterol. 2018. PMID: 29260300
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous