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Comment
. 2013 Feb 15;112(4):583-5.
doi: 10.1161/CIRCRESAHA.113.300964.

Of fish and men: clonal lineage analysis identifies divergence in myocardial development

Arun Sharma  1 , Sean M Wu
Affiliations
Comment

Of fish and men: clonal lineage analysis identifies divergence in myocardial development

Arun Sharma et al. Circ Res. .

Abstract

A clear understanding of myocardial development is essential not only for understanding of the molecular basis of congenital heart disease and its prevention but also for successful regeneration after cardiac injury. A recent study employed a novel Cre/LoxP-based lineage tracing approach with a multi-color reporter in zebrafish to examine the fates of populations of developing cardiomyocytes. The results showed that a remarkably few number of clones of cardiomyocytes are involved in the formation of adult zebrafish heart. Furthermore, a striking difference in the mechanism of myocardial compaction was described involving the creation of a completely new layer of cortical myocardium.

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Figures

Figure 1
Figure 1. Comparison of early myocardial development in chick, mouse, and zebrafish
A. Clonal analysis of cardiomyocyte precursor in chick by single cell retroviral tagging. B. Expansion of murine myocardial precursors cells at embryonic day 9.5. C. Development of cortical myocardial layer from trabecular cardiomyocytes in the zebrafish heart. Arrows represent cortical cardiomyocytes and their putative trabecular origin. Adapted with permission from references #, , and .
See this image and copyright information in PMC

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