Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Feb 11;23(2):137-9.
doi: 10.1016/j.ccr.2013.01.017.

Breaking news on fragile sites in cancer

Thomas W Glover  1 , Thomas E Wilson
Affiliations
Free article
Comment

Breaking news on fragile sites in cancer

Thomas W Glover et al. Cancer Cell. .
Free article

Abstract

Chromosome rearrangements in B lymphocytes can be initiated by AID-associated double strand breaks (DSBs), with others arising by unclear mechanisms. A recent study by Barlow and colleagues in Cell reports on genomic regions, termed early replicating fragile sites, that may explain many AID-independent DSBs and creates a compelling link between replication stress, transcription, and chromosome rearrangements.

PubMed Disclaimer

Comment on

LinkOut - more resources