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. 2013 Mar 6;135(9):3303-6.
doi: 10.1021/ja311783k. Epub 2013 Feb 22.

Retention or inversion in stereospecific nickel-catalyzed cross-coupling of benzylic carbamates with arylboronic esters: control of absolute stereochemistry with an achiral catalyst

Michael R Harris  1 , Luke E Hanna, Margaret A Greene, Curtis E Moore, Elizabeth R Jarvo
Affiliations

Retention or inversion in stereospecific nickel-catalyzed cross-coupling of benzylic carbamates with arylboronic esters: control of absolute stereochemistry with an achiral catalyst

Michael R Harris et al. J Am Chem Soc. .

Abstract

Stereospecific coupling of benzylic carbamates and pivalates with aryl- and heteroarylboronic esters has been developed. The reaction proceeds with selective inversion or retention at the electrophilic carbon, depending on the nature of the ligand. Tricyclohexylphosphine ligand provides the product with retention, while an N-heterocyclic carbene ligand provides the product with inversion.

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Figures

Scheme 1
Scheme 1
Control of product stereochemistry in stereospecific reactions
See this image and copyright information in PMC

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