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Comment
. 2013 Feb 13;13(2):123-5.
doi: 10.1016/j.chom.2013.01.015.

HIV-1: packaging a shifty genome?

Michael A Durney  1 , Victoria M D'Souza
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HIV-1: packaging a shifty genome?

Michael A Durney et al. Cell Host Microbe. .
Free article

Abstract

In this issue of Cell Host & Microbe, Chamanian et al. (2013) show that the frameshifting region in the HIV-1 genome influences the efficiency of genome packaging. This study may provide insights into mechanisms that constrain retroviruses into packaging only two copies of the genome during retroviral assembly.

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