Modeling cooperativity effects in dimeric G protein-coupled receptors

Abstract

G protein-coupled receptors organize into oligomeric arrangements to exert their function. In this chapter, three models of dimeric receptors, the two-state dimer receptor model, the metabotropic glutamate receptor model, and the asymmetric/symmetric three-state dimer receptor model are revisited focusing on the cooperative effects between their binding sites and the subunits they are composed of. The mathematical analysis reveals the complexity of the intra-receptor interactions providing insights on the mechanistic aspects of receptor function.