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. 2013:82:155-84.
doi: 10.1016/B978-0-12-407679-2.00005-3.

Mechanisms of immune evasion in leishmaniasis

Gaurav Gupta  1 , Steve Oghumu, Abhay R Satoskar
Affiliations

Mechanisms of immune evasion in leishmaniasis

Gaurav Gupta et al. Adv Appl Microbiol. 2013.

Abstract

Diseases caused by Leishmania present a worldwide problem, and current therapeutic approaches are unable to achieve a sterile cure. Leishmania is able to persist in host cells by evading or exploiting host immune mechanisms. A thorough understanding of these mechanisms could lead to better strategies for effective management of Leishmania infections. Current research has focused on parasite modification of host cell signaling pathways, entry into phagocytic cells, and modulation of cytokine and chemokine profiles that alter immune cell activation and trafficking to sites of infection. Immuno-therapeutic approaches that target these mechanisms of immune evasion by Leishmania offer promising areas for preclinical and clinical research.

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References

    1. Abu-Dayyeh I, Hassani K, Westra ER, Mottram JC, Olivier M. Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions. Infection and Immunity. 2010;78:2438–2445. - PMC - PubMed
    1. Abu-Dayyeh I, Shio MT, Sato S, Akira S, Cousineau B, Olivier M. Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif. PLoS Neglected Tropical Diseases. 2008;2:e305. - PMC - PubMed
    1. Aebischer T, Wolfram M, Patzer SI, Ilg T, Wiese M, Overath P. Subunit vaccination of mice against new world cutaneous leishmaniasis: comparison of three proteins expressed in amastigotes and six adjuvants. Infection and Immunity. 2000;68:1328–1336. - PMC - PubMed
    1. Afonso L, Borges VM, Cruz H, Ribeiro-Gomes FL, DosReis GA, Dutra AN, et al. Interactions with apoptotic but not with necrotic neutrophils increase parasite burden in human macrophages infected with Leishmania amazonensis. Journal of Leukocyte Biology. 2008;84:389–396. - PubMed
    1. Alexander J, Satoskar AR, Russell DG. Leishmania species: models of intracellular parasitism. Journal of Cell Science. 1999;112(Pt 18):2993–3002. - PubMed

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