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. 2013 Feb 14;152(4):673-84.
doi: 10.1016/j.cell.2013.01.041.

The origins and drivers of insulin resistance

Andrew M F Johnson  1 , Jerrold M Olefsky
Affiliations
Free article

The origins and drivers of insulin resistance

Andrew M F Johnson et al. Cell. .
Free article

Abstract

Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which precedes the development of type 2 diabetes mellitus and is thus the driving force behind the emerging diabetes epidemic. The precise causes of insulin resistance are varied, and the relative importance of each is a matter of ongoing research. Here, we offer a Perspective on the heterogeneous etiology of insulin resistance, focusing in particular on the role of inflammation, lipid metabolism, and the gastrointestinal microbiota.

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