Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jun;131(6):1272-1277.
doi: 10.1097/PRS.0b013e31828bd1a5.

The case for lower extremity allotransplantation

Matthew J Carty  1 , Ronald Zuker, Pedro Cavadas, Julian J Pribaz, Simon G Talbot, Bohdan Pomahac
Affiliations
Review

The case for lower extremity allotransplantation

Matthew J Carty et al. Plast Reconstr Surg. 2013 Jun.

Abstract

Background: Despite generally excellent success with vascularized composite allotransplantation at many body sites over the past two decades, vascularized composite allotransplantation as a treatment modality for lower extremity amputees has not yet been fully embraced.

Methods: The authors summarize the anticipated benefits of lower limb allotransplantation, and reference the likely controversies relevant to this restorative therapeutic modality.

Result: Based on evidence culled from both upper extremity and lower extremity transplant experience to date, the authors posit that allotransplantation for lower limb amputees may be a reasonable pursuit.

Conclusion: The authors advocate for the renewed consideration of lower extremity allotransplantation.

PubMed Disclaimer

References

    1. Pomahac B, Pribaz J, Eriksson E, et al. Three patients with full facial transplantation. N Engl J Med. 2012;366:715–722
    1. Knott PD, Hicks D, Braun W, Strome M. A 12-year perspective on the world’s first total laryngeal transplant. Transplantation. 2011;91:804–805
    1. Petruzzo P, Lanzetta M, Dubernard JM, et al. The International Registry on Hand and Composite Tissue Transplantation. Transplantation. 2010;90:1590–1594
    1. Levi DM, Tzakis AG, Kato T, et al. Transplantation of the abdominal wall. Lancet. 2003;361:2173–2176
    1. Ziegler-Graham K, MacKenzie EJ, Ephraim PL, et al. Estimating the prevalence of limb loss in the United States: 2005 to 2050. Arch Phys Med Rehabil. 2008;89:422–429

Publication types

Substances