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Review
. 2013 Apr 22;52(17):4526-37.
doi: 10.1002/anie.201204203. Epub 2013 Feb 18.

From one-photon to two-photon probes: "caged" compounds, actuators, and photoswitches

Guillaume Bort  1 , Thibault Gallavardin, David Ogden, Peter I Dalko
Affiliations
Review

From one-photon to two-photon probes: "caged" compounds, actuators, and photoswitches

Guillaume Bort et al. Angew Chem Int Ed Engl. .

Abstract

Molecular systems that can be remotely controlled by light are gaining increasing importance in cell biology, physiology, and neurosciences because of the spatial and temporal precision that is achievable with laser microscopy. Two-photon excitation has significant advantages deep in biological tissues, but raises problems in the design of "smart" probes compatible with cell physiology. This Review discusses the chemical challenges in generating suitable two-photon probes.

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