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Review
. 2013 Jul;60(7):1083-94.
doi: 10.1002/pbc.24487. Epub 2013 Feb 15.

Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors

Daniel M Green  1 , Larry E Kun, Katherine K Matthay, Anna T Meadows, William H Meyer, Paul A Meyers, Sheri L Spunt, Leslie L Robison, Melissa M Hudson
Affiliations
Review

Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors

Daniel M Green et al. Pediatr Blood Cancer. 2013 Jul.

Abstract

Children with solid tumors, most of which are malignant, have an excellent prognosis when treated on contemporary regimens. These regimens, which incorporate chemotherapeutic agents and treatment modalities used for many decades, have evolved to improve relapse-free survival and reduce long-term toxicity. This review discusses the evolution of the treatment regimens employed for management of the most common solid tumors, emphasizing the similarities between contemporary and historical regimens. These similarities allow the use of historical patient cohorts to identify the late effects of successful therapy and to evaluate remedial interventions for these adverse effects.

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Conflict of interest statement

Conflict of Interest Statement

Drs. Green, Kun, Matthay, Meadows, Meyer, Meyers, Spunt, Robison, and Hudson affirm that they have no affiliations that they consider to be relevant and important with any organization that to any author's knowledge has a direct interest, particularly a financial interest, in the subject matter discussed. Such affiliations include, but are not limited to, employment by an industrial concern, ownership of stock, membership on a standing advisory council or committee, a seat on the board of directors, or being publicly associated with a company or its products.

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