Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2013 Oct;21(10):2014-20.
doi: 10.1002/oby.20335. Epub 2013 May 25.

Satiety, but not total PYY, Is increased with continuous and intermittent exercise

M E Holmstrup  1 , T J Fairchild, S Keslacy, R S Weinstock, J A Kanaley
Affiliations
Randomized Controlled Trial

Satiety, but not total PYY, Is increased with continuous and intermittent exercise

M E Holmstrup et al. Obesity (Silver Spring). 2013 Oct.

Abstract

Objective: This study determined the hormonal and subjective appetite responses to exercise (1-h continuous versus intermittent exercise throughout the day) in obese individuals.

Design and methods: Eleven obese subjects (>30 kg/m(2) ) underwent three 12-h study days: control condition [sedentary behavior (SED)], continuous exercise condition [(EX) 1-h exercise], and intermittent exercise condition [(INT) 12 hourly, 5-min bouts]. Blood samples (every 10 min) were measured for serum insulin and total peptide YY (PYY) concentrations, with ratings of appetite (visual analog scale [VAS): every 20 min]. Both total area under the curve (AUC), and subjective appetite ratings were calculated.

Results: No differences were observed in total PYY AUC between conditions, but hunger was reduced with INT (INT < EX; P < 0.05), and satiety was increased with both SED and INT conditions (INT > EX and SED > EX; P < 0.05). A correlation existed between the change in total PYY and insulin levels (r = -0.81; P < 0.05), and total PYY and satiety (r = 0.80; P < 0.05) with the EX condition, not the SED and INT conditions.

Conclusions: The total PYY response to meals is not altered over the course of a 12-h day with either intermittent or continuous exercise; however, intermittent exercise increased satiety and reduced hunger to a greater extent than continuous exercise in obese individuals.

PubMed Disclaimer

Conflict of interest statement

There were no conflicts of interest for any of the authors of this manuscript.

Figures

Figure 1
Figure 1
Total PYY pattern of response over 12 h for the three study conditions. No significant differences across condition (P>0.05). ⇩- meal ingestion.
Figure 2
Figure 2
a) Hunger pattern of response over 12 h for the three study conditions. No significant differences by condition (P>0.05). ⇩- meal ingestion. formula image- exercise condition; 1-hour walking bout. ▯- intermittent exercise condition; hourly 5-minute walking bouts. b) 2 h tAUC for hunger VAS scores. *Significantly different from EX condition (P<0.05). †Significantly different from SED condition (P<0.05).
Figure 3
Figure 3
a) Satiety pattern of response over 12h for the three study conditions. No significant differences by condition (P>0.05). ⇩- meal ingestion. formula image- exercise condition; 1-hour walking bout. ▯- intermittent exercise condition; hourly 5-minute walking bouts. b) 2 h tAUC for satiety VAS scores. *Significantly different from SED and INT conditions (P<0.05).
See this image and copyright information in PMC

References

    1. McGowan BM, Bloom SR. Peptide YY and appetite control. Curr Opin Pharmacol. 2004;4(6):583–588. - PubMed
    1. Roth CL, Bongiovanni KD, Gohlke B, Woelfle J. Changes in dynamic insulin and gastrointestinal hormone secretion in obese children. J Pediatr Endocrinol Metab. 2010;23(12):1299–1309. - PubMed
    1. Batterham RL, Cohen MA, Ellis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med. 2003;349(10):941–948. - PubMed
    1. Jebb SA, Siervo M, Fruhbeck G, Goldberg GR, Murgatroyd PR, Prentice AM. Variability of appetite control mechanisms in response to 9 weeks of progressive overfeeding in humans. Int J Obes (Lond) 2006;30(7):1160–1162. - PubMed
    1. Hagobian TA, Sharoff CG, Stephens BR, et al. Effects of exercise on energy-regulating hormones and appetite in men and women. Am J Physiol Regul Integr Comp Physiol. 2009;296(2):R233–42. - PMC - PubMed

Publication types