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. 1990 Mar;30(3):159-62.
doi: 10.1002/jmv.1890300302.

Detection of hepatitis B viral DNA by polymerase chain reaction in patients with hepatitis B surface antigen

L N Shih  1 , J C Sheu, J T Wang, G T Huang, J S Chen, J L Sung, T H Wang, D S Chen
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Detection of hepatitis B viral DNA by polymerase chain reaction in patients with hepatitis B surface antigen

L N Shih et al. J Med Virol. 1990 Mar.

Abstract

Hepatitis B virus (HBV) DNA was assayed using the polymerase chain reaction in serum samples of 116 hepatitis B surface antigen (HBsAg) carriers, including 30 positive for hepatitis B e antigen (HBeAg) and 86 negative for HBeAg. In the HBeAg-positive group, all were positive for HBV DNA. In the HBeAg-negative group, 80.2% were positive for HBV DNA (80.0% in the healthy carrier group, 90.0% in the chronic active liver disease group, and 69.2% in patients with cirrhosis). This study indicated that every HBeAg-positive carrier as well as the majority of HBeAg-negative carriers were infectious and, in the latter group, that viral replication is most active in patients with chronic active liver disease.

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