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Case Reports
. 2013 Mar;48(3):232-5.
doi: 10.1016/j.pediatrneurol.2012.10.013.

Anti-N-methyl-d-aspartate encephalitis with ovarian cystadenofibroma

Oranee Sanmaneechai  1 , Joo Lee Song, Nicole Nevadunsky, Solomon L Moshé, Philip J Overby
Affiliations
Case Reports

Anti-N-methyl-d-aspartate encephalitis with ovarian cystadenofibroma

Oranee Sanmaneechai et al. Pediatr Neurol. 2013 Mar.

Abstract

We report the case of an adolescent girl with anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis who presented with focal seizures and hemichorea, followed by agitation, speech disturbance, mutism, and autonomic dysfunction. The institution of immunotherapy and removal of an ovarian cystadenofibroma led to full resolution of her symptoms with disappearance of serum NMDAR antibodies. This is the first report linking ovarian cystadenofibroma to anti-NMDAR encephalitis.

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Figures

Figure 1
Figure 1
Cranial magnetic resonance imaging (MRI) taken 14 days into clinical course revealed subtle areas of asymmetric increased signal intensity on fluid-attenuated inversion recovery (FLAIR) images involving the bilateral insular cortex.
Figure 2
Figure 2
Brain biopsy showed chronic meningitis with extension into the Virchow-Robin space and minimal activity in the brain parenchyma. The inflammatory infiltrate extended into the perivascular space (Hematoxylin & eosin staining; original magnification × 100).
Figure 3
Figure 3
Ovarian cyst consisting of polypoid excrescences with columnar ciliated epithelium lining and dense fibrous tissue (Hematoxylin & eosin staining; original magnification × 10).
See this image and copyright information in PMC

References

    1. Iizuka T, Sakai F, Ide T, et al. Anti-NMDA receptor encephalitis in Japan: Long-term outcome without tumor removal. Neurology. 2008;70:504–511. - PMC - PubMed
    1. Florance NR, Davis RL, Lam C, et al. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol. 2009;66:11–18. - PMC - PubMed
    1. Florance-Ryan N, Dalmau J. Update on anti-N-methyl-D-aspartate receptor encephalitis in children and adolescents. Curr Opin Pediatr. 2010;22:739–744. - PubMed
    1. Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: Case series and analysis of the effects of antibodies. Lancet Neurol. 2008;7:1091–1098. - PMC - PubMed
    1. Turner MR, Irani SR, Leite MI, Nithi K, Vincent A, Ansorge O. Progressive encephalomyelitis with rigidity and myoclonus: Glycine and NMDA receptor antibodies. Neurology. 2011;77:439–443. - PMC - PubMed

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