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Randomized Controlled Trial
. 2013 Jun;120(6):1227-31.
doi: 10.1016/j.ophtha.2012.11.039. Epub 2013 Feb 16.

One-year strabismus outcomes in the Infant Aphakia Treatment Study

Erick D Bothun  1 , Julia Cleveland, Michael J Lynn, Stephen P Christiansen, Deborah K Vanderveen, Dan E Neely, Stacey J Kruger, Scott R Lambert; Infant Aphakic Treatment Study
Collaborators, Affiliations
Randomized Controlled Trial

One-year strabismus outcomes in the Infant Aphakia Treatment Study

Erick D Bothun et al. Ophthalmology. 2013 Jun.

Abstract

Objective: To evaluate the characteristics of strabismus in infants who underwent cataract surgery with and without intraocular lens (IOL) implantation.

Design: Secondary outcome analysis in a prospective, randomized clinical trial.

Participants: The Infant Aphakia Treatment Study is a randomized, multicenter (n = 12), clinical trial comparing treatment of aphakia with a primary IOL or contact lens in 114 infants with a unilateral congenital cataract.

Intervention: Infants underwent cataract surgery with or without placement of an IOL.

Main outcome measures: The proportion of patients in whom strabismus developed during the first 12 months of follow-up was calculated using the life-table method and was compared across treatment groups and age strata using a log-rank test.

Results: Strabismus developed within the first 12 months of follow-up in 38 pseudophakic infants (life-table estimate, 66.7%) and 42 infants (life-table estimate, 74.5%) treated with contact lenses (P = 0.59). The younger cohort (<49 days) at the time of surgery demonstrated less strabismus (29 of 50; life-table estimate, 58.0%) than the older cohort (≥ 49 days; 51 of 64; life-table estimate, 80.0%; P<0.01).

Conclusions: Intraocular lens placement does not prevent the early development of strabismus after congenital cataract surgery. However, strabismus was less likely to develop in infants whose cataract was removed at an earlier age.

Financial disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

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Conflict of interest statement

No conflicting relationship exists for any author

Figures

Figure 1
Figure 1
Life-table estimates of the cumulative percent of patients demonstrating strabismus over time for all patients and for those without strabismus at baseline.
Figure 2
Figure 2
Life-table estimates of the cumulative percent of patients demonstrating strabismus over time according to age at the time of cataract surgery.
Figure 3
Figure 3
Histograms showing logarithm of the minimum angle of resolution (logMAR) visual acuity (VA) of treated eyes at 1 year of age. The numbers above the bars indicate the number of patients in the category. Median logMAR VA was 0.80 for orthotropic patients (n = 71) and 0.97 for nonorthotropic patients (n = 43). LP = light perception; LV = low vision.
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Comment in

References

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