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. 2013 Mar 28;49(25):2545-7.
doi: 10.1039/c3cc38100e.

X-ray triggered release of doxorubicin from nanoparticle drug carriers for cancer therapy

Zane B Starkewolf  1 , Larissa Miyachi, Joyce Wong, Ting Guo
Affiliations

X-ray triggered release of doxorubicin from nanoparticle drug carriers for cancer therapy

Zane B Starkewolf et al. Chem Commun (Camb). .

Abstract

Enhanced cellular toxicity was observed using X-ray irradiated nanoparticle drug carriers (NDC) consisting of doxorubicin (DOX) conjugated to DNA strands attached to the surface of gold nanoparticles. Kinetic studies showed that X-rays, acting as a triggering modality, generated reactive oxygen species to break DNA strands and release DOX.

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