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. 2013 Mar;28(2):147-53.
doi: 10.1177/1533317512475021. Epub 2013 Feb 18.

Predictors of cognitive decline in 85-year-old patients without cognitive impairment at baseline: 2-year follow-up of the octabaix study

Francesc Formiga  1 , Assumpta Ferrer, David Chivite, Jesus Alburquerque, Claudia Olmedo, Jose Maria Mora, María Labori, Ramón Pujol; Octabaix study members
Collaborators, Affiliations

Predictors of cognitive decline in 85-year-old patients without cognitive impairment at baseline: 2-year follow-up of the octabaix study

Francesc Formiga et al. Am J Alzheimers Dis Other Demen. 2013 Mar.

Abstract

Background/rationale: To determine how many 85-year-old community-dwelling patients with good cognitive performance at baseline maintain this level at 2-year follow-up.

Methods: We realized a longitudinal community-based study including 169 inhabitants. Patients who maintained scores >23 on the Spanish version of the Mini-Mental State Examination (MEC) were compared with the rest.

Results: A total of 144 individuals (85.2%) were found maintaining a MEC score >23. Under the combined criteria 110 (65%) presented no new cognitive decline. Multiple logistic regression analysis showed that maintaining a MEC score >23 was significantly associated with having a higher MEC score at baseline (P < .001, odds ratio 1.280, 95% confidence interval 1.104-1.484).

Conclusion: Most oldest-old patients with good cognitive function at baseline maintain this level at 2-year follow-up.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Formiga F, Ferrer A, Duaso E, Pujol R. Predictive items of 2-year mortality in nonagenarians with cognitive impairment at baseline: the NonaSantfeliu study. Arch Gerontol Geriatr. 2009;48(2):254–257. - PubMed
    1. Tilvis RS, Kähönen-Väre MH, Jolkkonen J, Valvanne J, Pitkala KH, Strandberg TE. Predictors of cognitive decline and mortality of aged people over a 10-year period. J Gerontol A Biol Sci Med Sci. 2004;59(3):268–274. - PubMed
    1. Hayden KM, Reed BR, Manly JJ, et al. Cognitive decline in the elderly: an analysis of population heterogeneity. Age Ageing. 2011;40(6):684–689. - PMC - PubMed
    1. Howieson DB, Camicioli R, Quinn J, et al. Natural history of cognitive decline in the old old. Neurology. 2003;60(9):1489–1494. - PubMed
    1. Formiga F, Ferrer A, Reñe R, Riera A, Gascon J, Pujol R. Factors predicting 2-year cognitive decline in nonagenarians without cognitive impairment at baseline: the NonaSantfeliu study. J Am Geriatr Soc. 2007;55(7):1152–1154. - PubMed