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Review
. 2013 Sep;16(3):413-8.
doi: 10.1007/s11102-013-0470-8.

Pituitary stem cells: candidates and implications

Farshad Nassiri  1 , Michael Cusimano, Jeff A Zuccato, Safraz Mohammed, Fabio Rotondo, Eva Horvath, Luis V Syro, Kalman Kovacs, Ricardo V Lloyd
Affiliations
Review

Pituitary stem cells: candidates and implications

Farshad Nassiri et al. Pituitary. 2013 Sep.

Abstract

The pituitary is the master endocrine gland of the body. It undergoes many changes after birth, and these changes may be mediated by the differentiation of pituitary stem cells. Stem cells in any tissue source must display (1) pluripotent capacity, (2) capacity for indefinite self-renewal, and (3) a lack of specialization. Unlike neural stem cells identified in the hippocampus and subventricular zone, pituitary stem cells are not associated with one specific cell type. There are many major candidates that are thought to be potential pituitary stem cell sources. This article reviews the evidence for each of the major cell types and discuss the implications of identifying a definitive pituitary stem cell type.

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