Autoantibodies against cytokines: back to human genetics
- PMID: 23429982
- DOI: 10.1182/blood-2013-01-474213
Autoantibodies against cytokines: back to human genetics
Abstract
In this issue of Blood, Chi et al have discovered that the occurrence of autoantibodies against IFN-γ, which trigger mycobacterial diseases and mimic inborn errors of IFN-γ immunity, is genetically determined.(1)
Comment on
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Anti-IFN-γ autoantibodies in adults with disseminated nontuberculous mycobacterial infections are associated with HLA-DRB1*16:02 and HLA-DQB1*05:02 and the reactivation of latent varicella-zoster virus infection.Blood. 2013 Feb 21;121(8):1357-66. doi: 10.1182/blood-2012-08-452482. Epub 2012 Dec 13. Blood. 2013. PMID: 23243276
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