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Review
. 2013:7:93-8.
doi: 10.2147/DDDT.S37324. Epub 2013 Feb 13.

An early indicator of drug success: Top Journal Selectivity Index

Igor Kissin  1
Affiliations
Review

An early indicator of drug success: Top Journal Selectivity Index

Igor Kissin. Drug Des Devel Ther. 2013.

Abstract

The Top Journal Selectivity Index (TJSI) is a scientometric index reflecting the potential importance of a new drug. It represents the ratio of the number of all types of articles on a particular drug in the top 20 journals relative to the number of articles in all (>5,000) biomedical journals covered by Medline over the 5 years since the drug's introduction. The TJSI can be an indicator of a drug's potential for sustained use: a higher score increases the probability of continuing success.

Keywords: bibliometrics; pharmaceutical market; scientometrics; ‘me-too’ drugs.

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Figures

Figure 1
Figure 1
Example of Top Journal Selectivity Indices (TJSI) of first-in-class drugs (FICD) with multiple follow-on drugs (FOD) in six pharmacological classes.Note: Columns represent TJSI: the ratio of the number of all types of articles on a particular drug in the top 20 journals to the number of articles in all (>5000) biomedical journals covered by Medline (PubMed), both over 5 years since the drug’s introduction.Abbreviations: ACE, angiotensin-converting enzyme; PPI, proton pump inhibitors; NRTI, nucleotide reverse transcriptase inhibitors.
Figure 2
Figure 2
The relationship between TJSI and success score in the development of new analgesics.Note: The correlation coefficient (r) for TJSI and success score is 0.876 (P < 0.001).Abbreviations: TJSI, Top Journals Selectivity Index; To, topiramate; D, duloxetine; P, pregabalin; Zo, zolmitriptan; Tr, tramadol; R, remifentanil; Zi, ziconotide; C, celecoxib; G, gabapentin; S, sumatriptan.
Figure 3
Figure 3
The relationship between TJSI of follow-on drugs (FOD) without distinguishing features (“me-too” drugs) and the order (sequential number) of drugs’ market entry.Notes: Along vertical axis – TJSI: Top Journal Selectivity Index presented as a fraction of first-in-class drug (FICD), calculated for each class separately. Along horizontal axis – sequential number of market entry for FOD starting with number 2 (number 1 is left for FICD). Circles indicate various follow-on drugs without distinguishing features (43 drugs).
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References

    1. Agarwal P, Searls DB. Can literature analysis identify innovation drivers in drug discovery? Nat Rev Drug Discov. 2009;8:865–877. - PMC - PubMed
    1. Bordons M, Bravo C, Barrington S. Time-tracking of the research profile of a drug using bibliometric tools. J Am Soc Inf Sci Technol. 2004;55:45–61.
    1. Windsor DA. Could bibliometric data be used to predict the clinical success of drugs? J Doc. 1976;32:174–181.
    1. Windsor DA. Bibliometrics and drugs. J Chem Inform Comput Sci. 1980;20(4):255.
    1. Kissin I. Can a bibliometric indicator predict the success of an analgesic? Scientometrics. 2011;86:785–795.

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